Webinar on Studying Neural Mechanisms in Small and Large Animals by Using High Density Electrophysiological Recordings

　　DATE: Tuesday, June 28, 2022

　　TIME:

　　- 11:00 am PT (Pacific Time - North America)

　　- 2:00 pm ET (Eastern Time - North America)

　　- 7:00 pm GMT (Greenwich Mean Time)

　　-北京时间 2022 年 6 月 29 日，星期三，上午 2:00

　　DURATION: 60 MIN

　　在本次网络研讨会中，来自NYU Grossman School of Medicine的Dr. Michael Long和来自Vanderbilt University的Dr. Kari Hoffman将和大家分享他们使用Diagnostic Biochips高密度硅探针在小型和大型动物中研究学习、记忆和行为的神经机制的研究工作。

　　In this webinar, Dr. Michael Long from the NYU Grossman School of Medicine and Dr. Kari Hoffman from Vanderbilt University will present their work investigating the neural mechanisms of learning, memory, and behavior using high-density silicon probes from Diagnostic Biochips in small and large animals.

　　The ability to record network activity using emerging high-density electrophysiological arrays has revolutionized understanding of the link between brain function and behavior. In the first portion of the webinar, Dr. Long will discuss how his laboratory has used custom-built (and now standard) probes to investigate the neural mechanisms of vocal production in two model systems: the zebra finch (a songbird) and a newly characterized Costa Rican singing mouse. In ongoing work, they have begun to apply these approaches to the study of human speech. His team has collaborated with Diagnostic Biochips and the University of Iowa Department of Neurosurgery to develop a recording electrode for measuring population activity in the human brain. Through these combined efforts, they have advanced understanding of the neural mechanisms of vocal production that can inform therapeutic approaches intended to combat a range of communication disorders.

　　In the second portion of the webinar, Dr. Hoffman will introduce work in her lab investigating the neural mechanisms of learning and memory in freely-behaving macaques. This includes recording neural signatures from animals in a rich environment to examine how experiences shape new learning. Using spatially resolved units, distinct waveforms, and interactions with local currents and fields, they hope to identify the role of functional cell types in network states and network plasticity. Dr. Hoffman will also describe the features and current limitations of the probe, and present preliminary wireless recording results from her lab. She will conclude with a discussion of factors that may make it more or less suitable for other users, and best practices for generating high quality data.

　　本次研讨会主题包括：

　　-了解 Diagnostic Biochips 深部电极的主要特点

　　-如何使用一些动物模型研究声音交流的神经机制

　　-Speech planning是由人脑中的特定皮层位点介导的

　　-高密度记录可以研究不同脑区对发声的作用的相关网络模型

　　-猕猴实现 256 通道的无线记录

　　-在选择、植入和使用电极时要考虑的重要因素

　　注册链接：https://insidescientific.com/webinar/using-high-density-electrophysiological-recordings-to-investigate-neural-mechanisms-in-small-and-large-animals/

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　　Silicon Probe硅电极

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　　该电极阵列在不锈钢材质的探针上集成了多达128个微电极记录位点，能够在非人灵长类和其他大型动物上进行长期慢性和急性记录。